What Role Do Sex Chromosomes Play In Transgender People’s Identities?

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What role do sex chromosomes play in the identities of transgender people? originally appeared on Quorathe place to gain and share knowledge, empowering people to learn from others and better understand the world.

Answer by Sai Janani Ganesan, Postdoctoral Scholar at UCSF, on Quora:

Biological gender and gender identity are two very distinct concepts. Biological gender or sex refers to the anatomy and physiology of a human body, whereas gender identity is influenced by a multitude of factors, most of which we don’t fully understand.

Biological sex is purely determined by the choice of sexual differentiation pathway, which is guided by genes on the sex chromosomes (though not exclusively, for example: WNT4 on chromosome 1).Testis-determining factor (TDF) or sex determining gene Y (SRY) located on the Y chromosome is one such gene. SRY is largely responsible for testis formation. It is not the only gene, and a variety of pathways and proteins are involved in this process of sex differentiation, some even located in the autosomal regions, but SRY is… special.

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